Web  Lecture - McEwen - page 5 - slides # 25-30
Go to Slides #1-6, #7-12, #13-18, #19-24, #25-30, #31-36 , #37-41
 
"Sex, Stress and the Hippocampus: Receptors, Intracellular Mechanisms and Synaptic Plasticity"
Bruce S. McEwen, PhD

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Slide 25: Hippo. is important target of estrogen action, despite the fact that it contains relatively few estrophilic neurons (compared to hypothalamus and amygdala).
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Slide 26: Women treated with GRH agonist had memory problems. Concurrent estrogen replacement reversed memory deficits.
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Slide 27: CA-1 pyramidal neuronal morphology changes during estrus cycle in the rat. (i.e. increased # dendritic spines with increased estrogen)
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Slide 28: Radioimmunocytochemistry technique can be used to study synapse formation.
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Slide 29: Estrogen treatment induces increased a presynaptic marker protein.
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Slide 30: Estrogen treatment increases spinophyllin levels.  May enhance maturation of spines, rather than induce new synapses.
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